8537 Greenbriar St. || Wichita KS || 67226 || 316-796 4110
MAGNETIC NANOPARTICLE HEATING &
HYPERTHERMIA INSTRUMENT
2026-2027
Magnetic Hyperthermia: (In Vitro / In Vivo Cancer Research)
(1) Tumor Targeting
(2) Drug Release on Command
(3) Drug Penetration into Tumor
(4) Killing Bacterial Infections
(5) Stem Cell Activation
Comparative DOX Delivery Paradigms for Heat Responsive Liposomes
Summary: The key difference between the tumor models is vascular permeability. Temperature triggered drug release and simultaneous hyperthermia heating increased microvascular permeability and drug infusion by 9-fold. M. Dewhirst, NanoScale Drug Delivery and Hyperthermia, 2011. pp. 38-60
Nanoparticle Heating / Magnetic Hyperthermia
Breast / Brain Cancer Research/ Stem Cell Research
Treating Drug Resistant Infections
Features:
A. Heating Power: 5.0-7.0 KW
B. Dual RF Inverter: 100-450 kHz / 500-900 kHz
C. Magnetic Power Intensity: (30-60 mT / High SAR values)
D. Round Heating Coils: 40–130 mm / Helmholtz Heating Coils
E. Hand-Portable Planar Coil: 35-55 mm tissue depth penetration
F. Computer Controls Heating Power to Remain within NIH Safe Level for Humans
TECHNOLOGY REPORT: The physiology of the tumor is one of the key factors responsible for the failure of chemotherapy: (1) High hydrostatic pressure of tumors and limited blood flow prevents drugs to easily penetrate tumor tissue rich with cancer cells. (2) Cancer cell’s cumulative resistance to repetitive drug treatments. (3) Damaging effects of drug toxicity on non-targeted and healthy tissue. (4) Absence of a useful system to remotely trigger the release of the cancer drug specifically at the site of the tumor.
MAGNETIC HEATING of temperature sensitive magnetic nanocarriers allows targeted release of the cancer drug. (P. Pradhan) Further, low temperature heating can improve microvascular permeability of the tumor. This allows the drug to more easily penetrate the cancer tissue and restrict the growth of the tumor. (M. Dewhirst)
The Magnetic Hyperthermia System has many features. It can be used with heating coil diameters from 40-130 mm. It can be used with a IBIDI Petri dish so that the nanoparticles in a solution can be observed live and photographed from above with a microscope. The larger diameter coils can be used for live animal cancer research, such as with mice, rabbits and cats. Special coils are available for treating foot and leg infections—a serious condition affecting thousands of diabetic patients worldwide.
COILS CAN BE INTERCHANGED. EACH COIL OPERATES AT ITS OWN RESONANT FREQUENCY FROM 150-450 KHZ.
The System Automatically adjusts to the correct Frequency.
*Coils can be oriented vertically or horizontally.
*Coil Diameters can be between 40-130 mm.
*Planar coils are available for heating flat surfaces.
Measuring the Temperature Response of Magnetic Nanoparticles.
Neoptix Fiber Optic Temperature Measurement of the Nanoparticles in the Glass Vial (above).
Rising Temperature Profile (Above)
Magnetic Field Measurement Probe is Used to Measures and Display the Magnetic Field Strength of Each Heating Coil.
Adjustable Heating Coil Voltage. Development of meaningful data beyond small animal study to reach human trials requires a range of coil diameters. By use of the variable voltage feature, the larger coils up to 130 mm will have similar heating energy of the smaller test coils. It is the larger coils that equate to the size of the some of the body human parts.
Having sufficient (1) heating power, (2) frequency range and the correct (3) heating coil voltage allows for more accurate research results.
Breast Cancer is the Most Common Form of Cancer.
It is the best application of Magnetic Hyperthermia because the heating coil can be shaped into a cup-shape to encompass the breast. This shape is the most efficient in terms of delivering heating power inward to the tumor.
Magnetic Hyperthermia is effective as a treatment method because the heating coil can be shaped to fit the dimensions of the breast. The Round Heating Coil can be Sized and Shaped to Match the Breast Dimensions.
If the Nanoparticles are injected into the Tumor shown here, only the Tumor will Heat. The surrounding Healthy Tissue will not heat.
Heating and Killing Bacterial Foot Infections.
Magnetic Hyperthermia Treatment (AMF): Tissue samples taken from live patients whose infections spread despite antibiotic treatment. (C) E-Coli infected muscle sample. (D) E-Coli infected bone sample. Both treatments were exposed to magnetic- hyperthermia heating (AMF) for 5-15 minutes. Longer exposure results in higher death rate for the bacteria. Scanning electron microscope images revealed the destruction of the bacterial cell wall. AMF treatment also resulted in excess reactive oxygen species formation, which might contribute to accelerated bacteria cell death. A 3-5 log reduction in bacterial load post-AMF showed the potential of magnetic-hyperthermia-induced treatment to control bacterial infections-- of all bacterial pathogens. (As Required by the FDA: A lengthy safety study of 25 female rats showed an overall lack of significant edematous response to AMF.) (Journal of the Royal Society of Chemistry 2022: NanoScale,14. 1713…)
Treating Foot Ulcers / Foot Infections
80% of Foot Ulcers result in foot infections
PHOTO: Infected foot has failed antibiotic treatment. Magnetic Hyperthermia succeeds by heating bacteria’s naturally acquired iron nanoparticles. The infection stops. Bacteria die. There is no harm to the surrounding healthy tissue.
Magnetic Hyperthermia Foot Tunnel: Minor skin infections or a Foot Ulcer (DFU) must be treated immediately or within 24 hours of detection of the infection.. This MSI system begins killing the bacteria in minutes, not hours or days. Five 15 minute sessions in a week’s time can completely cancel the infection of the foot and prevent possible amputation.. (Send for MSI Document R14ZZ)
Traditional Antibiotic Treatment is hampered by drug-resistant bacteria (AMR). The World Health Organization (WHO) states that bacteria are mutating at an accelerated rate and becoming more drug-resistant as fast as new antibiotics are arriving at clinics and hospitals.
Additionally, Peripheral Vascular Disease (PVD) is common with diabetic patients. This disease slows or prevents the antibiotics from reaching the infection. This results in the undeterred spread of the foot infection. Once the infection reaches the bones, amputation of the foot will be required.
The MSI SYSTEM uses a computer algorithm to control the heating power so that the magnetic power (Frequency (f) x Magnetic Field (H)) does not exceed the limit established by the FDA for treating human body parts.
Rear View of Power Supply Cabinet
Rear of the Cabinet: Power Disconnect Switch, Circuit Breaker, Water Inlet and Outlet, Pressure Gauge, Control Cable to Heat Station.
Interface Connections:
1. +24 VDC Auxiliary Supply
2. Fiber Optic Sensors (2)
3. Magnetic Field Sensor
4. USB Port
5. Type J Thermocouple Socket
6. External Control Cable Socket
7. RS-232 / RS-485 Ports
8. Aux.
SPECIFICATIONS:
POWER LEVELS AVAILABLE: 5.0, 7.0, 10.0 and 12.0 KW
AC VOLTAGE: SINGLE PHASE 208-240 VAC 50/60 Hz / THREE PHASE: 240-480 VAC / 20-30 AMPS
AVAILABLE FREQUENCY RANGE: 100-500 KHZ (100-800 KHZ OPTIONAL)
WATER COOLING: 12 LITERS/MINUTE @ 2 BAR (30 PSI)
WATER CHILLER: 8000 BTU
DIMENSIONS
POWER SUPPLY: 27.5” (60 cm) Length x 14.5” (35 cm) High x 21” (50m) Wide
Weight: 120 LBS. (60 kilos)
HEAT STATION: 10” (25 cm) Wide x 12” ((30 cm) High x 18” (45 cm) Long
Weight: 40 lbs. (20 kilos)
CABLE BETWEEN POWER SUPPLY AND HEAT STATION: 1-2 METER
SOLENOID HEATING COIL DIAMETER: 40-80 mm (STANDARD) / 90-110 mm (LARGER SIZES ARE AVAILABLE)
HAND UNIT PLANAR COIL: 50 mm DIAMETER
HEAT STATION AND HAND UNIT SELECTOR SWITCH
USER INTERFACE / COMMUNICATION:
COLOR TOUCH SCREEN / LOCAL OR REMOTE CONTROL
DIGITAL CYCLE TIMER / BUILT INTO THE TOUCH SCREEN
DIGITAL TEMPERATURE CONTROLLER / RS-485
ETHERNET CONNECTION TO REMOTE LAPTOP COMPUTER / EASYLINK SOFTWARE (AVAILABLE)
TEMPERATURE MEASUREMENT PROBE: SINGLE OR DUAL
TEMPERATURE MEASUREMENT SOFTWARE: NEOPTIX OPTILINK AND RS-232 CABLE INCLUDED
